Genes classified as having specificity in the Myocyte_3 group include the regulatory proteins Troponin C2, fast type ( TNNC2), Myosin binding protein C2, fast isoform ( MYBPC2), and ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ( ATP2A1), responsible for calcium reuptake into the sarcoplasmic reticulum. Genes classified as having specificity in the Myocyte_2 group include the sarcoglycan complex subunit Sarcoglycan gamma ( SGCG), which links the myocyte cytoskeleton to the extracellular matrix, as well as Calcium voltage-gated channel subunit alpha1 S ( CACNA1S), involved in calcium regulation, and Protein phosphatase 1 regulatory subunit 3A ( PPP1R3A), which is important for the metabolism of glycogen in muscle fibers. Genes classified as having specificity in the Myocyte_1 group include the contractile protein Myosin light chain 6B ( MYL6B), the regulatory protein Troponin C1, slow type ( TNNC1), as well as the uncharacterized protein C12orf75, with unknown function. Skeletal muscle myofibers can be separated into two main types, termed fast-twitch and slow-twitch. The contractile function of muscle cells is controlled by actin and myosin myofilaments, which form small repeating subunits known as sarcomeres which are then arranged together and aligned to form very long, repeating myofibrils, which give skeletal muscle its distinctive striated or striped pattern. Skeletal muscle cells consist of many individual striated muscle cells that are fused together into long, multinuclear myofibers. Skeletal muscle cell type enriched transcriptome: Illustrative examples Skeletal myocytes Bar plot of the number of enriched genes in the cell types of the skeletal muscle, divided by specificity category Number of genes in each specificity category in the skeletal muscle cell types.įigure 1. other profiled cell types within the tissue >0.15
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